Curious about clinical trials?

Access the latest treatments and medications. unavailable elsewhere - entirely free of charge. We make it easy to take part.

What is Cymbalta (duloxetine)?

Duloxetine is a generic drug sold under the brand name Cymbalta.

Cymbalta is a serotonin and norepinephrine reuptake inhibitor (SNRI). Doctors prescribe it to treat mood disorders like depression and anxiety, but it can also be used to treat pain and muscle problems.

SNRIs work by increasing serotonin and norepinephrine activity in the brain, which helps regulate mood.

What is Cymbalta used to treat?

Cymbalta can be prescribed to people with depression or anxiety. It can also help people with diabetes, fibromyalgia, or other conditions that cause musculoskeletal problems or neuropathy (numbness or tingling in the extremities).

How do you take Cymbalta?

Cymbalta is prescribed as an oral capsule. The capsules are available in 20mg, 30mg, and 60mg doses. Your doctor will prescribe a dose¹ based on your health condition.

Musculoskeletal pain and fibromyalgia

For musculoskeletal pain and fibromyalgia, the normal starting daily dose is 30mg increased to 60mg depending on how you respond to treatment.

For people aged 13 years and older, the recommended dosage is 30mg once a day. If there are no adverse effects, your doctor can increase the dosage to 60mg.

Diabetes and neuropathy

People with diabetes and neuropathy may need to start with a lower dose because of possible renal complications. Doses higher than 60mg are not advisable for this condition.


A starting dose of 40–60mg is recommended for people with depression. Your doctor may put you on a dosing schedule of 20mg or 30mg twice daily, or 60mg once per day. Your doctor can raise your dose to 120mg if necessary.

If you need to take Cymbalta twice a day, you should take it in the morning and in the evening.

Generalized anxiety disorder

Your doctor may prescribe 60mg once per day to treat generalized anxiety disorder (GAD) if you’re under 65. If you’re older than 65, a daily dose of 30mg for at least 14 days is recommended. If there are no side effects, your dose could be increased to 60mg per day.

Doctors recommend 30–60mg daily for children aged seven and above. They can take 30mg for the first two weeks, to be increased to 60mg if they have no side effects.

Seeing results 

You might notice improvements in your sleep, energy levels, and appetite within the first two weeks.² It could take three months to experience Cymbalta’s full effects on your mood.

Potential side effects of Cymbalta

Cymbalta may cause side effects, including:

Serious physical side effects of Cymbalta may include:

  • Liver damage with complications

  • Hypotension (low blood pressure)

  • Severe bleeding

  • Severe skin allergies

  • Swelling in the face or extremities

Serious psychological side effects of Cymbalta may include:

  • Increased thoughts of suicide among people aged up to 24

  • Hallucinations

  • Agitation

  • Restlessness

  • Confusion

  • Delusions

Seek medical help if you develop serious side effects when taking Cymbalta. Less serious side effects may go away unaided, but see your doctor about long-lasting or worsening adverse effects.

Long-term use of Cymbalta

Cymbalta is suitable for long-term use. Although taking this drug may cause side effects, there are no proven long-term, harmful effects of using the drug.

Missed doses

Missing doses of Cymbalta may reduce its effectiveness and cause your symptoms to return.

If you forget to take a dose, take it as soon as possible. Don’t take a missed dose if it’s almost time for your next dose. Never take two doses at once.


Taking more than the recommended dose could lead to overdose, increasing your risk of side effects and serious, long-lasting complications.

Overdose symptoms may include hypotension, hypertension, vomiting, serotonin syndrome, and even coma. To ensure that you do not overdose, carefully follow your doctor’s instructions.

If you think you or someone else has taken too much Cymbalta, seek medical attention urgently.

What to discuss with your doctor before taking Cymbalta

Before taking Cymbalta, talk to your doctor about the following things:

  • Allergies: Tell your doctor if you are allergic to any medications, including Cymbalta or any of its ingredients.

  • Other medications: Your doctor needs to know if you are taking any other medications, prescription or nonprescription. Some medications can interact with Cymbalta, reducing its effectiveness or causing complications.

  • Supplements and herbal remedies: Tell your doctor if you take or plan to take any nutritional supplements or herbal remedies as they may interact with Cymbalta.

  • Drugs and alcohol: Tell your doctor if you regularly consume alcohol or drugs.

  • Pregnancy: If you are pregnant, breastfeeding, or planning to get pregnant, tell your doctor before taking Cymbalta.

You must also tell your doctor if you will be undergoing surgery, including dental surgery. Be sure to make medical and dental professionals aware that you’re taking Cymbalta before having surgery.

Tell your doctor if you have thoughts of suicide or have suicidal tendencies, as Cymbalta may be unsuitable for you.

Stopping Cymbalta 

Stopping Cymbalta suddenly without first talking to your doctor may cause withdrawal symptoms. Only stop taking Cymbalta if your doctor tells you to.

If you want to stop taking this medication, discuss it with your doctor. They can help you stop taking Cymbalta safely.

Cymbalta and pregnancy

Taking Cymbalta after 13 weeks of pregnancy may increase your risk of delivering preterm.² Discuss the potential benefits and risks of taking this medication with your doctor.

Duloxetine (Cymbalta) can be passed to the child in small quantities in breastmilk. Tell your doctor if you are breastfeeding before taking Cymbalta.

Interactions with other drugs

Cymbalta can interact with other drugs, so you must tell your doctor about all medications you currently take or plan to take. Drugs that may interact with Cymbalta include:

  • Other antidepressant drugs, including monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and other SNRIs

  • Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen

  • Triptans (a class of drugs used to treat migraines and other symptoms)

  • Stimulant drugs

  • Some types of antibiotics

  • Blood thinners, such as aspirin and warfarin

  • Other drugs that cause gastric acidity

These drugs may interact with Cymbalta, changing the way it affects your body and potentially causing complications, such as increased side effects.

Allergy information

Skin allergies are one of the more common side effects of Cymbalta. Other allergic reactions may include difficulty breathing and swelling.

If you experience any signs of an allergic reaction to Cymbalta (like hives or difficult breathing), or a severe skin reaction (like fever, sore throat, burning eyes, painful skin rashes with blisters and peeling), seek immediate medical attention.

Clinical trial history

The United States Food and Drug Administration (FDA) approved Cymbalta based on four randomized, double-blind, placebo-controlled studies³ in patients with major depressive disorder aged 18 to 83 years.

In two of these studies, participants were randomized to take a placebo or 60mg of Cymbalta once daily. The trial lasted nine weeks.

In a third study that took place over eight weeks, participants were randomized to take 20 or 40mg of Cymbalta twice daily, or a placebo.

In a fourth study that lasted eight weeks, participants were randomized to take 40 or 60mg of Cymbalta twice daily, or a placebo.

Using the Hamilton Depression Rating Scale, participants were rated after the studies had ended to assess the effectiveness of Cymbalta. In all four studies, Cymbalta was found to improve depression symptoms more than the placebo.

Tips and advice for taking Cymbalta

Keep these tips in mind when taking Cymbalta to improve your experience and keep you safe:

  • Take Cymbalta before or after eating, with or without food. It should be swallowed whole, not chewed or crushed.

  • Follow your doctor’s instructions carefully to increase your chance of seeing results and avoid side effects.

  • Avoid consuming alcohol when taking Cymbalta as it could increase your risk of liver damage.

  • Cymbalta may impair your reactions, so avoid activities like driving or operating heavy machinery until you know how the drug affects you.

  • Inform your doctor immediately if you have any serious side effects when taking Cymbalta, including hallucinations or suicidal thoughts.

  1. Cymbalta dosage | Medical News Today

  2. Duloxetine (Cymbalta) | National Alliance of Mental Illness

  3. Cymbalta (duloxetine delayed-release capsules) | Center Watch

 Other sources:

Curious about clinical trials?

Access the latest treatments and medications. unavailable elsewhere - entirely free of charge. We make it easy to take part.

Explore related clinical trials

Actively recruiting
Major Depressive Disorder Study
Actively recruiting
The Candesartan Adjunctive Major Depression Trial - CADET: A double-blind, randomised, placebo-controlled trial
Actively recruiting
XEN1101 for Major Depressive Disorder

Here at HealthMatch, we’ve done our best to ensure that the information provided in this article is helpful, up to date, and, most importantly, accurate.

However, we can’t replace the one-to-one advice of a qualified medical practitioner or outline all of the possible risks associated with this particular drug and your circumstances.

It is therefore important for you to note that the information contained in this article does not constitute professional medical or healthcare advice, diagnosis or recommendation of treatment and is not intended to, nor should be used to, replace professional medical advice. This article may not always be up to date and is not exhaustive of all of the risks and considerations relevant to this particular drug. In no circumstances should this article be relied upon without independent consideration and confirmation by a qualified medical practitioner.

Your doctor will be able to explain all possible uses, dosages, precautions, interactions with other drugs, and other potential adverse effects, and you should always talk to them about any kind of medication you are taking, thinking about taking or wanting to stop taking.

Curious about clinical trials?

Access the latest treatments and medications. unavailable elsewhere - entirely free of charge. We make it easy to take part.