Amitriptyline is a prescription drug for various mental health conditions. It is a tricyclic antidepressant that alters the levels of serotonin and norepinephrine in the brain.
Amitriptyline is available as 10mg, 25mg, 50mg, 75mg, 100mg or 150mg tablets.
Amitriptyline treats a variety of conditions, including:
Amitriptyline is a tricyclic antidepressant (TCA), FDA-approved in 1961¹. It increases levels of serotonin and norepinephrine, two neurotransmitters that play a role in mood regulation.
You will usually take a single pill of amitriptyline once a day. Taking it before bedtime is ideal because it can make you drowsy. If you are still sleepy in the morning, consider taking it earlier in the evening.
Most people see results within the first few weeks of taking amitriptyline. However, it can take up to two months for the medication to reach its full potential. Side effects such as drowsiness and dry mouth usually improve as your body adjusts to the drug.
If you don't see any improvement after a couple of months, talk to your doctor about increasing your dosage or trying a different medication. Don't stop taking amitriptyline suddenly, as this can cause withdrawal symptoms.
Common side effects of amitriptyline include:
Other side effects include:
Changes in sex drive or ability
If you experience any of these side effects, contact your doctor.
Amitriptyline may also cause more severe side effects. These include:
If you experience any of these side effects, seek medical attention immediately.
Most people tolerate amitriptyline well, but it is essential to be aware of the potential side effects and risks before starting treatment. If you are concerned about any of these, speak to your doctor.
Amitriptyline is a highly regarded medicine that is relatively safe over long periods. There do not appear to be any detrimental effects associated with using it for lengthy periods.
Amitriptyline is not addictive. However, if you stop taking it suddenly, you might experience withdrawal symptoms.
Long-term use of amitriptyline can result in dependence, where your body relies on the substance and develops a tolerance. It is essential to take the medication exactly as prescribed, and do not stop taking the medication without consulting your doctor.
You can take amitriptyline with or without food. If you miss a dose of amitriptyline, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses of amitriptyline together unless directed to do so by your healthcare provider.
An amitriptyline overdose can be deadly, and you should always treat it as a medical emergency. Symptoms of an amitriptyline overdose may include:
If you or someone you know has overdosed on amitriptyline, call 911 or immediately go to the nearest emergency room.
Have a discussion with your doctor before taking any new medication. This is especially important with amitriptyline because it can have serious side effects. Some of the things you should discuss with your doctor are:
Your medical history
Any other medications you are taking
Any allergies you have
If you are pregnant or breastfeeding
Your alcohol use
Your drug use
Your doctor will also want to know if you have ever had a heart attack, seizures, glaucoma, or any mental health conditions like depression, bipolar disorder, or schizophrenia. You must tell your doctor about all of these things to determine if amitriptyline is right for you.
You should always taper off amitriptyline slowly under the supervision of your doctor to avoid withdrawal symptoms. Symptoms of stopping too quickly can include:
Taking amitriptyline during pregnancy does not usually require any additional monitoring of your baby. If you took amitriptyline around the time of delivery, your newborn might require closer observation after birth because of the potential danger of neonatal abstinence syndrome (NAS). NAS is where your baby experiences withdrawal from the drug you were taking.
Amitriptyline excretes into human milk. If you take amitriptyline and breastfeed, your baby may experience drowsiness, poor feeding, or weight gain. Speak to your doctor about this.
You should avoid drinking alcohol while taking amitriptyline because it can increase the effects of alcohol. This can make you more likely to experience side effects such as drowsiness, dry mouth, blurred vision, constipation, and difficulty urinating. It can also worsen depression.
If you must drink alcohol while taking amitriptyline, drink plenty of fluids to avoid dehydration.
You should avoid taking amitriptyline with other drugs that can cause drowsiness, such as:
Narcotic pain relievers
Taking amitriptyline with these drugs can increase the risk of side effects such as:
Amitriptyline can also interact with other medications such as:
Blood thinners (e.g., warfarin)
Heart rhythm medications (e.g., quinidine)
MAO inhibitors (e.g., tranylcypromine)
High blood pressure medications (e.g., beta-blockers such as atenolol)
Seizure medications (e.g., carbamazepine)
Diabetes medications (e.g., insulin)
Thyroid medications (e.g., levothyroxine)
Amitriptyline can also interact with other drugs that are not listed here. Tell your doctor about all the medicines you take, including over-the-counter and herbal medications. Do not start or stop taking any medication without first talking to your doctor.
Amitriptyline may cause a condition called serotonin syndrome when taken with other drugs such as:
Selective serotonin reuptake inhibitors (SSRIs)
Serotonin and norepinephrine reuptake inhibitors (SNRIs)
Tricyclic antidepressants (TCAs)
Monoamine oxidase inhibitors (MAOIs)
Symptoms of serotonin syndrome may include:
Shivering or shaking
The risk of serotonin syndrome increases when you take these drugs together. You should avoid taking amitriptyline with other medications that can cause serotonin syndrome. If you experience any of the symptoms listed above, stop taking amitriptyline and call your doctor immediately.
Amitriptyline may cause a severe reaction called anaphylaxis, which can be life-threatening. It requires immediate medical attention. Tell your doctor if you are allergic to amitriptyline or any other medications.
Do not take this medication if you are allergic to amitriptyline or if you have:
A history of heart attack, stroke, or blood clots
Coronary artery disease
High blood pressure
History of seizures
If you have any of these conditions, you may need a dose adjustment or special tests to take this medication safely.
According to one study², low back pain is a primary clinical and public health concern, with limited evidence-based therapies available. Doctors often use low-dose antidepressants to treat chronic low back discomfort. However, their effectiveness is unproven. This pragmatic, double-blind, placebo-controlled study aimed to see whether low-dose amitriptyline was more effective than a placebo in reducing pain in those with chronic persistent back discomfort.
Researchers found that among the sample of 146 participants with chronic low back pain, low-dose amitriptyline did not help improve pain, disability, or work at six months. Still, it reduced disability at the 3-month mark and improved pain intensity³. Additionally, there were minimal adverse effects reported among participants who used amitriptyline.
Amitriptyline is considered a good alternative to prescription pain medications³, like opioids, since it is safer and has fewer adverse side effects.
When it comes to medications, everyone is different. What works for one person might not work for another. When it comes to amitriptyline, keep a few things in mind before taking it.
First and foremost, always consult with your doctor before starting any new medication. They will tell you if amitriptyline is the proper medication for you and what dosage best suits your needs.
Second, make sure you take amitriptyline precisely as your doctor prescribed. Do not increase or decrease the dosage without talking to your doctor first. Doing so could lead to unpleasant side effects.
Finally, give amitriptyline time to work. It might take a few weeks before you start to feel the full effects of the medication. Be patient, and don't give up. With time, amitriptyline can improve your quality of life.
Here at HealthMatch, we’ve done our best to ensure that the information provided in this article is helpful, up to date, and, most importantly, accurate.
However, we can’t replace the one-to-one advice of a qualified medical practitioner or outline all of the possible risks associated with this particular drug and your circumstances.
It is therefore important for you to note that the information contained in this article does not constitute professional medical or healthcare advice, diagnosis or recommendation of treatment and is not intended to, nor should be used to, replace professional medical advice. This article may not always be up to date and is not exhaustive of all of the risks and considerations relevant to this particular drug. In no circumstances should this article be relied upon without independent consideration and confirmation by a qualified medical practitioner.
Your doctor will be able to explain all possible uses, dosages, precautions, interactions with other drugs, and other potential adverse effects, and you should always talk to them about any kind of medication you are taking, thinking about taking or wanting to stop taking.